Ed Feser has a provocative article about scientism, which he defines this way: Scientism is the view that all real knowledge is scientific knowledge—that there is no rational, objective form of inquiry that is not a branch of science. His critique is that Despite its adherents’ pose of rationality, scientism has a serious problem: it is either self-refuting or trivial.

Take the first horn of this dilemma. The claim that scientism is true is not itself a scientific claim, not something that can be established using scientific methods. Indeed, that science is even a rational form of inquiry (let alone the only rational form of inquiry) is not something that can be established scientifically. For scientific inquiry itself rests on a number of philosophical assumptions: that there is an objective world external to the minds of scientists; that this world is governed by causal regularities; that the human intellect can uncover and accurately describe these regularities; and so forth. Since science presupposes these things, it cannot attempt to justify them without arguing in a circle….
the second horn of the dilemma facing scientism. Its advocate may now insist: if philosophy has this status, it must really be a part of science, since (he continues to maintain, digging in his heels) all rational inquiry is scientific inquiry. The trouble now is that scientism becomes completely trivial, arbitrarily redefining “science” so that it includes anything that could be put forward as evidence against it….
Conservatives, more than anyone else, should be wary of the pretensions of scientism, a Procrustean ideology whose pretensions were exposed with particular insight by F. A. Hayek, one of the great heroes of contemporary conservatives (including, perhaps especially, secular conservatives—Hayek himself was an agnostic with no religious ax to grind). …Hayek shows that the project of re-conceiving human nature in particular entirely in terms of the categories of natural science is impossible in principle.

The reason has to do with what Hayek calls the “objectivism” inherent in scientism. Modern science arose in large part out of a practical, political concern—to make men “masters and possessors of nature” (as Descartes put it), and enhance “human utility and power” through the “mechanical arts” or technology (in the words of Francis Bacon).
…Hayek’s view was that the very nature of objectivism precludes its coherently being applied across –the board to the human mind itself. Since the mind just is the “subjective” realm of so-called “appearances”—the rug under which everything that does not fit the “objectivist” method has been swept—it cannot even in theory be assimilated via quantificational modeling to the material world, as that world has been characterized by physical science. …
The irony is that the very practice of science itself, which involves the formulation of hypotheses, the weighing of evidence, the invention of technical concepts and vocabularies, the construction of chains of reasoning, and so forth—all mental activities saturated with meaning and purpose—falls on the “subjective,” “manifest image” side of scientism’s divide rather than the “objective,” “scientific image” side. Human thought and action, including the thoughts and actions of scientists, is of its nature irreducible to the meaningless, purposeless motions of particles and the like. Some thinkers committed to scientism realize this, but conclude that the lesson to draw is not that scientism is mistaken, but that human thought and action are themselves fictions. …
But as Hayek would have predicted, the very attempt to state the position necessarily, but incoherently, makes use of concepts—“science,” “rationality,” “evidence,” “truth,” and so forth—that presuppose exactly what the position denies, viz. the reality of meaning and mind.

Read it all here.